UK-MHRA Drug-Related Suicide Reports_Yellow Card

 It is estimated to represent 1 in 100 adverse drug events that occur. However, as there is no control, the number of incidents do not inform us about the rate at which these events occured or possible contributing factors other than the drug.

 

 SUICIDE ACCOMPLISHED             MHRA stats from Yellow Cards       2004

 

Drug Substance

No of Reports

1          fluoxetine

62

2          paroxetine

38

3          clozapine

27

4          venlafaxine

17

= 5       sertraline

15

= 5       isotretinoin

15

=7        citalopram

9

=7        dothiepin

9

=7        moclobemide

9

= 10     risperidone

8

= 10     zopiclone

8

12        olanzapine

7

= 13     amitriptyline

6

= 13     mefloquine

6

= 13     quetiapine

6

= 16     fluphenazine

5

= 16     fluvoxamine

5

= 18     bupropion

4

= 18     diazepam

4

= 18     thioridazine      

4

 

 

NON-ACCIDENTAL OVERDOSE

 

Drug Substance

No of Reports

1          paroxetine

36

2          olanzapine

29

= 3       paracetamol

28

= 3       venlafaxine

28

= 5       bupropion

17

= 5       clozapine

17

= 5       fluoxetine

17

8          sertraline

15

9          citalopram

14

= 10     carbamazepine 

9

= 10     codeine           

9

=12      amitriptyline

8

=12      dothiepin

8

=12      zopiclone

8

=12      dextropropoxyphene

8

16        quetiapine

7

17        moclobemide

6

 

                         

OVERDOSE N.O.S.

 

Drug Substance

No of Reports

1              clozapine

109

2              venlafaxine

50

3              paroxetine

41

4              fluoxetine

35

5              paracetamol

29

6              bupropion

26

= 7           citalopram

24

= 7           zopiclone

24

9              olanzapine

19

= 10         dothiepin

18

= 10         sertraline

18

12            tramadol

16

13            quetiapine

14

14            amitriptyline

13

= 15         aspirin

11

= 15         carbamazapine

11

= 15         diazepam

11

18            diamorphine

10

= 19         dihydrocodeine

8

= 19         risperidone

8

 

SUICIDAL IDEATION                                                      

 

Drug Substance

No of Rpts

 1             fluoxetine

125

2              bupropion

74

3              paroxetine

57

4              isotretinoin

18

5              mefloquine

17

= 6           citalopram

11

= 6           efavirenz

11

= 6           mirtazapine

11

= 6           sertraline

11

= 6           venlafaxine

11

11            zopiclone

8

= 12         medroxyprogesterone

7

= 12         oestradiol

7

= 12         topiramate

7

= 15         levonorgestrel

6

= 15         nefazadone

6

= 15         norethisterone

6

= 15         simvastatin

6

= 19         amlodipine

5

= 19         atenolol

5

= 19         clarithromycin

5

= 19         etoricoxib

5

= 19         fluvoxamine

5

= 19         gabapentin

5

= 19         lamotrigine

5

= 19         levetiracetam

5

= 19         rofecoxib

5