1950: Two-hundred female prisoners infected with viral hepatitis

1974: President Nixon signed the National Research Act establishes National Commission for the Protection of Human subjects, requiring Public Health Service to promulgate regulations for the protection of human subjects. Title 45 of the Code of Federal Regulations, later known as “The Common Rule,” requires the appointment and utilization of…

1958–1962: An Atomic Energy Commission field study — “Project Chariot” — spread radioactive materials over Inupiat land in Point Hope, Alaska. Today, cancer is the leading cause of death in Point Hope. Alaska Dispatch, 2012.

US Army and State Department funded a crash program to develop new drugs against malaria. The largest single CMR malaria experiment involved 800 prisoners at federal penitentiary in Atlanta, New Jersey State Reformatory and Illinois State Penitentiary. A series of experiments were conducted at Stateville Penitentiary by medical researchers from…

1947–1953: U.S. Navy Project CHATTER focused on identifying and testing drugs for interrogations and recruitment of intelligence agents. CIA Mind Control

1966: Animal Welfare Act establishes ethical use of laboratory animals in research. There is no law protecting human research subjects from unethical experimentation. 1966: Henry Beecher’s article “Ethics and Clinical Research” in New England Journal of Medicine identified 50 unethical clinical studies. But it would be eight years before a…

Scientific evidence existed showing the vaccine was contaminated with a cancer causing monkey virus — simian virus 40 (SV40) — but public health officials refused to take precautionary action. An estimated 98 million Americans received the Salk Polio vaccine. “Few back then grasped that these vaccines might also be a…