Posts Tagged ‘Publication Bias’
The Truth Wears Off
The excerpts from The New Yorker (below) may be read as a companion piece to the Atlantic article profiling Dr. John Ioannidis. However, the opening example that Lehrer uses to make the point that initial impressive positive research findings often weaken in time, perpetuates a myth about the new antipsychotics, a myth promulgated by…
Read MoreThe Damaging Impact of PDUFA and Why It Should be Repealed
The re-prioritization of rapid approvals occurred at the expense of drug safety standards,
Read MoreReminder BBC Panorama-Secrets of the Drug Trial
The first in the BBC-Panorama series elicited more than 65,000 emails and phone calls.The fourth report aired tonight, focuses on study #329, the largest of the Paxil pediatric trials. BBC will show evidence of how the published report of this trial was manipulated to deceive physicians about the safety and efficacy findings. [see Friday's Infomail…
Read MoreNEJM- Caught Covering Up for National Kidney Foundation–an indudstry front group
Readers of the New England Journal of Medicine should be forewarned: The information in the pages of the NEJM is tainted by industry influence, its professional and scientific integrity are tainted.
Read MoreNegative Research Results–Mostly Concealed in Journals_SharonBegley, WSJ
"Why are scientists coy about publishing negative data?
Read MoreAre SSRIs and Atypical Antidepressants Safe/ Effective for Children/ Adolescents/ Neonates?
Are SSRIs and Atypical Antidepressants Safe / Effective for Children / Adolescents/ Neonates? Wed, 2 Mar 2005 The American psychiatric establishment continues to operate within a “head in the sand” culture of denial when confronted with compelling evidence that has been scientifically replicated showing that their prescribing of antidepressants for children has been misguided. They…
Read MoreA Taxpayer-Funded Clinical Trial Registry Exists!
A Taxpayer-Funded Clinical Trial Registry Exists! Thu, 6 Oct 2005 A former FDA medical officer reports: A Taxpayer-Funded Clinical Trials Registry and Results Database: It already exists within the US Food and Drug Administration. But the agency keeps the vital information about drug safety secret and inaccessible. So, all the while that clinical trial analysts,…
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The Evidence base: rock of certainty or shifting sands? – BMJ Wed, 5 May 2004 Dr. John Dewhurst, has written an extraordinary article from his first-hand experience as a pharmaceutical company physician who discovered the disparity that exists between the claimed and actual evidence of drug effectiveness–and the reality-based severe, debilitating adverse effects of antidepressants.…
Read MoreInt’l Registration of Clinical Research WHO
Int’l Registration of Clinical Research WHO Tue, 6 Apr 2004 On April 3, the World Health Organization (WHO) and Current Controlled Trials, Ltd (based in London, Philadelphia and Tokyo) announced that all randomized controlled clinical trials approved by the WHO ethics committee will be registered in a unique international registry of research. Such trials will…
Read More"Black Hole" of medical research–Negative Results Don’t get Published – JAMA, WSJ
“Black Hole” of medical research–Negative Results Don’t get Published – JAMA, WSJ Sat, 5 Jun 2004 “No one likes bad news. But in science, there is an ethical imperative to publish research, even if the findings aren’t what the researcher had hoped for.” The New York Times, which tends to report even preliminary, unpublished and…
Read More"Drug Companies Should Make Their Studies Public" NYT
“Drug Companies Should Make Their Studies Public” NYT Wed, 13 Aug 2003 Concealed and inaccessible research findings are undermining the integrity of medicine, the advancement of scientific knowledge, and most importantly, secrecy is putting people’s lives in jeopardy because prescribing doctors are ignorant about adverse – even lethal – drug effects. Recently disclosed evidence –…
Read MoreBritish Psychiatrists Debate: "Clinical trials of antidepressant medications are producing meaningless results"
British Psychiatrists Debate: “Clinical trials of antidepressant medications are producing meaningless results” Wed, 27 Aug 2003 “The fact that most people support the psychopharmacological orthodoxy is, in itself, no argument and it is important to examine the evidence before drawing conclusions.” The psychiatric establishment is on trial–its foundation and claimed scientific basis and method–at least…
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