1714: Charles Maitland, Smallpox

Richard Strong, MD, a professor of tropical medicine at Harvard, conducted cholera experiments on 24 prisoners in the Philippines killing thirteen. Their deaths were attributed to the accidental substitution of bubonic plague serum for cholera. He rewarded the survivors with cigars. During the Nazi trials at Nuremberg, the defendants cited…

Dr. Armauer Hensen, a Norweigian microbiologist who discovered the bacterium that causes leprosy, having failed to grow the bacterium in a petri dish or any experimental animal, he tried to inoculate leprosy into the eye of a woman without her consent or knowledge. In 1880, she sued him in a…

In the first century B.C. Cleopatra devised an experiment to test the accuracy of the theory that it takes 40 days to fashion a male fetus fully and 80 days to fashion a female fetus. When her handmaids were sentenced to death under government order, Cleopatra had them impregnated and…

Advisory Committee on Human Radiation Experiments (ACHRE) Report Ch. 2, 1995. Lawrence Altman. Who Goes First? The Story of Self-Experimentation in Medicine, 1988 Appeal from the Lübeck Decision, Journal of the American Medical Association (JAMA), 1932 Nicholas Bakalar.  Where the Germs Are: A Scientific Safari, 2003 Edwin Black. War Against…

The Hippocratic medical ethics oath is attributed to Hippocrates, and was adopted as a guide to the  medical profession conduct throughout the ages and still used in the graduation ceremonies of many medical schools. In essence, the Hippocratic Oath: “Primum non nocere” (“First do no harm” or “Above all, do…

William C Black MD conducted unethical medical experiments on children. He wrote a report about an experiment in which he had infected a 12-month old baby with herpes. Francis Payton Rous, editor of the Journal of Experimental Medicine, rejected Black’s manuscript and wrote an editorial in the Journal stating: “I cannot…