1714: Charles Maitland, Smallpox

Yellow fever epidemics struck the United States repeatedly in the 18th and 19th centuries. The disease was not indigenous; epidemics were imported by ship from the Caribbean. Dr. Reed decided against self-experimentation and injected 22 Spanish immigrant workers in Cuba instead with the agent for yellow fever. He paid them…

Luther Emmett Holt, a professor of children’s disease at Columbia University, was accused of conducting 1,000 tuberculin tests on sick and dying babies at NY Babies’ Hospital. (Grodin and Glantz, Children As Research Subjects)

U.S. Supreme Court upheld a Virginia forced sterilization statute of people considered “genetically unfit.” Harvard-educated eugenicist, Oliver Wendell Holmes’ infamous declaration, “Three generations of imbeciles are enough. . .” resulted in the forced sterilization not only of Carrie Buck of Charlottesville, Virginia, who was falsely “diagnosed” as mentally deficient and…

Hideyo Noguchi, MD, of the Rockefeller Institute for Medical Research injected a syphilis preparation into 146 children — 100 were institutionalized and 46 were healthy — in an attempt to develop a skin test for syphilis. Several parents sued Dr. Noguchi for infecting their children with syphilis. (Noguchi. Journal of…

J. Marion Sims performed multiple experimental surgeries on enslaved African women without the benefit of anesthesia. After suffering unimaginable pain, many lost their lives to infection. One woman was made to endure 34 experimental operations for a prolapsed uterus. Read: Wendy Brinker, 2002.

Biomedical research in Germany was considered the most advanced in the world — both in its development and its ethics standards. Berlin Code of Ethics (1900) guaranteed that “all medical interventions for other than diagnostic, healing, and immunization purposes, regardless of other legal or moral authorization are excluded under all…