1714: Charles Maitland, Smallpox

Cornelius Rhoads, MD, a prominent, Harvard trained pathologist conducted a cancer experiment in Puerto Rico under the auspices of the Rockefeller Institute for Medical Investigations resulting in the death of thirteen subjects. He was accused of purposely infecting his Puerto Rican subjects with cancer cells after a Puerto Rican physician…

Arthur Wentworth, MD, a pediatrician trained at Harvard Medical School, performed spinal taps on 29 babies and young children at Children’s Hospital, Boston, to determine if the procedure was harmful. Dr. John Roberts of Philadelphia, noting the non-therapeutic indication, labeled Wentworth’s procedures “human vivisection.” (Grodin and Glantz, Children As Research…

Alfred Hess & Mildred Fish used orphans as guinea pigs in studies testing dietary factors in rickets and scurvy by withholding essential nutrients from institutionalized infants until they developed the disease. Orange juice was withheld until the infants developed hemorrhages associated with Scurvy. Konrad Bercovici, a social worker, strongly criticized…

“Leaders of the American Medical Association briefly considered amending the organization’s code of ethics to include the provision that human experimentation calling for the knowledgeable permission of the subject. The AMA leadership decided not to adopt such a stance believing it both unnecessary in light of the good moral character…

Joseph Goldberger, MD, under orders of the US Public Health Office induces Pellagra, a debilitating fatal disease affecting the central nervous system, in twelve Mississippi inmates in an attempt to discover treatments for the disease. He determined that the disease was caused by niacin (Vitamin B3) deficiency. But the Public…