1885: Louis Pasteur

Louis Pasteur, a French chemist, microbiologist who laid the foundation for vaccines. After testing the rabies vaccine in 50 dogs, he tested the vaccine on 9-year-old Joseph Meister who was bitten by a rabid dog with a physician in attendance. The experiment was controversial and he was brought before the…

1896: Arthur Wentworth MD

Arthur Wentworth, MD, a pediatrician trained at Harvard Medical School, performed spinal taps on 29 babies and young children at Children’s Hospital, Boston, to determine if the procedure was harmful. Dr. John Roberts of Philadelphia, noting the non-therapeutic indication, labeled Wentworth’s procedures “human vivisection.” (Grodin and Glantz, Children As Research…

1897: Giuseppe Sanarelli, MD

Giuseppe Sanarelli, MD, Italian bacteriologist injects the bacillus causing yellow fever five patients without their consent. Three of the five patients died. Dr. William Osler publicly admonished Sanarelli, stating: “To deliberately inject a poison of known high degree of virulency into a human being, unless you obtain the man’s sanction,…