1714: Charles Maitland, Smallpox

U.S. Public Health Service begins a 25-year Syphilis experiment at Tuskegee, Alabama, involving 400 black sharecroppers. The purpose of the experiment was to study the natural course of untreated syphilis in Negro men. Notwithstanding the participation of black institutions, doctors and the pivotal nurse Eunice Rivers, the underlying premise of…

U.S. Supreme Court upheld a Virginia forced sterilization statute of people considered “genetically unfit.” Harvard-educated eugenicist, Oliver Wendell Holmes’ infamous declaration, “Three generations of imbeciles are enough. . .” resulted in the forced sterilization not only of Carrie Buck of Charlottesville, Virginia, who was falsely “diagnosed” as mentally deficient and…

William C Black MD conducted unethical medical experiments on children. He wrote a report about an experiment in which he had infected a 12-month old baby with herpes. Francis Payton Rous, editor of the Journal of Experimental Medicine, rejected Black’s manuscript and wrote an editorial in the Journal stating: “I cannot…

Hideyo Noguchi, MD, of the Rockefeller Institute for Medical Research injected a syphilis preparation into 146 children — 100 were institutionalized and 46 were healthy — in an attempt to develop a skin test for syphilis. Several parents sued Dr. Noguchi for infecting their children with syphilis. (Noguchi. Journal of…

Louis Pasteur, a French chemist, microbiologist who laid the foundation for vaccines. After testing the rabies vaccine in 50 dogs, he tested the vaccine on 9-year-old Joseph Meister who was bitten by a rabid dog with a physician in attendance. The experiment was controversial and he was brought before the…

Dr. Armauer Hensen, a Norweigian microbiologist who discovered the bacterium that causes leprosy, having failed to grow the bacterium in a petri dish or any experimental animal, he tried to inoculate leprosy into the eye of a woman without her consent or knowledge. In 1880, she sued him in a…