1973: Final Report of Tuskegee Syphilis Study
1973: The Final Report of Tuskegee Syphilis Study concluded: “Society can no longer afford to leave the balancing of individual rights against scientific progress to the scientific community.”
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1961: Public Health Officials’ Criminal Culpability in Contaminated Polio Vaccine Disaster
In July, 1961, Merck and Parke-Davis recalled their Salk vaccines — without mentioning the cancer risk. NIH officials concealed the SV40 cancer risk and never recalled the rest of the polio vaccine supply. Even after they knew that the vaccine was infected, they continued to expose millions of Americans to…
1953–1954: Multi-Site NIH Cooperative Study of Premature Babies’ Survival
NIH Multi-Site Cooperative Study of Retrolental Fibroplasia (RLF, later called, ROP), a form of blindness in premature babies was conducted at 18 hospitals nationwide. The first recorded case of RLF in a premature baby was in 1942 in Boston, decades after premature babies had been routinely provided unrestricted oxygen during…
1955–1963: Dark Side of Salk Polio Vaccine
Scientific evidence existed showing the vaccine was contaminated with a cancer causing monkey virus — simian virus 40 (SV40) — but public health officials refused to take precautionary action. An estimated 98 million Americans received the Salk Polio vaccine. “Few back then grasped that these vaccines might also be a…
1967: Human Guinea Pigs: Experimentation on Man
1967: British physician Maurice Pappworth published Human Guinea Pigs: Experimentation on Man; he was far less circumspect than Beecher. He identified researchers by name and provided their institutional affiliations, stating bluntly: “No doctor, however great his capacity or original his ideas, has the right to choose martyrs for science or…
1967–1968: California prisoners were paralyzed with a neuromuscular agent
Sixty-four California prisoners were paralyzed with succinylcholine, a neuromuscular agent that restricts breathing. Succinylcholine has since been used in lethal injection protocols. When five prisoners in the California experiment refused to participate as subjects in the experiment, researchers were given “permission” to inject the recalcitrant prisoners against their will. (Harriet…
1966: “Ethics and Clinical Research”
1966: Animal Welfare Act establishes ethical use of laboratory animals in research. There is no law protecting human research subjects from unethical experimentation. 1966: Henry Beecher’s article “Ethics and Clinical Research” in New England Journal of Medicine identified 50 unethical clinical studies. But it would be eight years before a…