A widely prescribed hypertensive drug for managing high blood pressure, drug for children labeled with ADHD and adults with post traumatic stress
disorder (PTSD), Guanfacine, is yet another worthless FDA-approved psychotropic drug. Dr. Thomas Neylan, medical director PTSD program at San
Francisco, VA., who conducted “the first-ever randomized, placebo-controlled trial for the alleviation of post-traumatic stress
disorder (PTSD)” reports: “we found that it really offered patients no benefits of any symptoms.” 
“While failing to demonstrate a single symptom benefit, this drug comes with serious adverse side effects including: cardiovascular abnormalities, liver
abnormalities. The serious psychiatric adverse effects include: agitation, anxiety, confusion, depression, insomnia, nervousness. These are hardly trivial. In fact, the drug appears to have the potential of TRIGGERING the symptoms of PTSD. (American J of Psychiatry, Dec. 2006)
Why did a pill that should have worked so well in theory fall flat in practice? The answer, we believe, fits ALL the failed psychotropic “wonder drugs.”Psychiatry’s theoretical base is bankrupt. Psychiatry has promoted the myth that antidepressants, antipsychotics, anti-convulsants act by correcting a presumed “chemical imbalance” in the brain. However, the “chemical imbalance” theory has been promoted without a shred of scientific evidence. 
The “authoritative” claims that psychoactive drugs of one class or another restore “normal chemical balance” in the brain is an invention of drug
manufacturers’ marketing divisions. What’s worse, leading “authorities” in academic psychiatry became consultants and financial stakeholders in the
industry, then provided industry’s marketing claims with the appearance of “scientific” legitimacy. Leading academics in psychiatry argued that depression is caused by serotonin deficiency–ergo, since SSRI antidepressants raise serotonin levels, they are the treatment of choice for depression.
The fallacy with that argument (as others have commented), is that it rests on the absurd claim that because aspirin relieves headaches, someone with a
headache is “aspirin deficient.” Of course, the difference is, aspirin works to relieve headaches, antidepressants have failed to demonstrate in controlled trials that they work better than a sugar pill.
Dr. Randall Marshall, director of Trauma Studies and Services at New York State Psychiatric Institute stated, “I was so shocked that I had to think about it for two days. I was trying to find a hole in the science and I can’t – this is a state-of-the-art clinical trial. The effect size was zero — there’s no hint of a benefit.” Read more here <https://ahrp.org/cms/content/view/407/9/>
The psychiatrists and other mental health professionals who have promoted this market-driven myth traded their professional integrity. Unfortunately that indictment is applicable to 90% of those who make up the mental health industry.
1. SOURCES: Thomas Neylan, M.D., medical director, PTSD treatment program, San Francisco VA Medical Center, and associate professor, psychiatry,
University of California, San Francisco; Radnall Marshall, director, Trauma Studies and Services, New York State Psychiatric Institute, New York City;
Dec. 1, 2006, American Journal of Psychiatry)
Study co-authors were Maryann Lenoci, MA, and Kristin W. Franklin, PhD, of SFVAMC; Thomas J. Metzler, MA, of UCSF and SFVAMC; Clare Henn-Haase, PsyD, of SFVAMC; Robert W. Hierholzer, MD, of UCSF and Fresno VA Medical Center, Fresno, Calif.; Steven E. Lindley, MD, PhD, of Stanford University and Palo Alto VA Medical Center, Palo Alto, Calif.; Christian Otte, MD, of UCSF, SFVAMC, and University Hospital Hamburg-Eppendorf, Germany; Frank B.
Schoenfeld, MD, of UCSF and SFVAMC; Jerome A. Yesavage, MD, of Stanford University and PAVAMC; and Charles R. Marmar, MD, of SFVAMC and UCSF.
The study was funded by support from the Department of Veterans Affairs.
Contact: Vera Hassner Sharav
Common PTSD Drug May Be Useless Study finds guanfacine offers no benefit and carries risks.
By E.J. Mundell
FRIDAY, Dec. 1 (HealthDay News) — A drug long used to treat post-traumatic stress disorder appears to have done patients no good and may even have done
In the first-ever randomized, placebo-controlled trial of guanfacine for the alleviation of post-traumatic stress disorder (PTSD), “we found that it
really offered patients no benefits of any symptoms, and we looked at a lot of symptoms,” said lead researcher Dr. Thomas Neylan, medical director of
the PTSD treatment program at the San Francisco VA Medical Center.
“We looked at whether people were feeling less anxious, whether they were sleeping better, whether they startled less, whether they were having fewer
intrusive memories,” said Neylan, who is also an associate professor of psychiatry at the University of California, San Francisco. “But in anything
that we looked at, we found there was no benefit for the drug over placebo.”
The study results may come as a surprise to psychiatrists and patients, since guanfacine and a related drug, clonidine, have been used for years to
“They are commonly used, but what we hope now is that people shy away from using clonidine and guanfacine,” Neylan said.
One expert said he was taken aback by the findings.
“I was so shocked that I had to think about it for two days. I was trying to find a hole in the science and I can’t — this is a state-of-the-art clinical trial,” said Dr. Randall Marshall, director of Trauma Studies and Services at New York State Psychiatric Institute. “Their effect size was zero — there’s no hint of a benefit.”
The study, which was funded by the U.S. Department of Veterans Affairs, is published in the Dec. 1 issue of the American Journal of Psychiatry.
Guanfacine’s rise and apparent fall as a PTSD treatment may be an object lesson in why randomized, controlled trials — such as the one Neylan’s
group conducted — are so important to assessing a drug’s worth, he said.
Guanfacine and clonidine are alpha-2 agonists, which means they bind to the alpha-2 receptor on brain cells, blocking the release of a neurotransmitter
called norepinephrine, Neylan explained. Norepinephrine is the neural form of the stress hormone adrenalin. Psychiatrists have long known that PTSD
patients have increased levels of norepinephrine activity in their brains.
“So, from the start, the whole idea was very appealing — you give a drug like guanfacine that blocks the effects of norepinephrine, and you’d hope to
see some benefit,” he said. “It made intuitive sense. It was a lovely idea.”
In fact, it was such an attractive idea that more than 20 review articles and guidelines, published in a variety of psychiatric journals, touted the
use of guanfacine and clonidine in easing PTSD symptoms.
But no one had ever put this idea to the test in a randomized, controlled trial.
In its eight-week study, Neylan’s group compared the effects of guanfacine and an identical-looking placebo pill in 63 male and female veterans
diagnosed with PTSD. Twenty-nine participants were randomly picked to take guanfacine while the other 34 took the dummy pill.
By the end of the study, the researchers found no net difference between the two groups in terms of changes in symptoms.
“But the one thing that did clearly come out was that there were more side effects with guanfacine,” Neylan said. “There was more sedation, feeling
fatigued, dry mouth.”
Why did a pill that should have worked so well in theory fall flat in practice? Neylan offered one possible answer. “[Too much] norepinephrine can
be a bad thing,” he noted, “but you also need it for your brain to work well. So, lowering the whole pool of norepinephrine did not seem to be an
He said the relatively small sample size in the study means he can’t be absolutely certain that alpha-2 agonists have no benefit, “but we did get a
zero effect size. That means that even if we had 5 or 6 times this sample, the probability of showing a meaningful difference is really, really low.”
Marshall agreed that the methodology is sound, and the findings conclusive. “I think this pretty much answers the question of whether, in this
population, guanfacine should be considered as either a primary or an adjunctive treatment. The answer is no — it’s a big surprise,” he said.
The finding will change the way he and psychiatrists everywhere treat PTSD patients, said Marshall, who is also associate director of the Anxiety
Disorders Clinic and an associate professor of clinical psychiatry at the Columbia University College of Physicians and Surgeons. He believes that,
despite the anecdotal success of guanfacine in isolated cases, “We should not generalize that to PTSD or treatment-refractory PTSD.”
Neylan said a newer drug that works on norepinephrine receptors, but in a different way, might still succeed where guanfacine has failed.
That drug, called prazosin, blocks the alpha-1 receptor in the synapse. “There have been a few trials to show that prazosin does have some promise,
and I know the VA is gearing up to do a large multi-site study. It is becoming more popular.”
In the meantime, he said, it’s important to remember that the first-line therapy for most people with PTSD is antidepressants and/or psychotherapy,
especially “exposure therapy,” where patients are gently confronted with reminders of the traumatic event itself.
“Most people feel that PTSD benefits most from a combination of pharmacologic treatment and psychotherapy,” Neylan said.
Moe information. To learn more about PTSD, head to the U.S. National Institute of Mental Health <http://www.nimh.nih.gov/healthinformation/ptsdmenu.cfm> .
(SOURCES: Thomas Neylan, M.D., medical director, PTSD treatment program, San Francisco VA Medical Center, and associate professor, psychiatry, University
of California, San Francisco; Radnall Marshall, director, Trauma Studies and Services, New York State Psychiatric Institute, New York City; Dec. 1, 2006,
American Journal of Psychiatry)
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NOTE PSYCHIATRIC ADVERSE EFFECTS: agitation, anxiety, confusion, depression, insomnia
An open-label postmarketing study involving 21,718 patients was conducted to assess the safety of guanfacine (as the hydrochloride) 1 mg/day given at
events reported in the postmarketing study at an incidence greater than 1% included dry mouth, dizziness, somnolence, fatigue, headache
LESS FREQUENT, possibly guanfacine related events observed in the postmarketing study and/or reported spontaneously include:
BODY AS A WHOLE asthenia, chest pain, edema, malaise, tremor
CARDIOVASCULAR bradycardia, palpitations, syncope,
CENTRAL NERVOUS SYSTEM paresthesias, vertigo
EYE DISORDERS blurred vision
GASTROINTESTINAL SYSTEM abdominal pain, constipation, diarrhea, dyspepsia
LIVER AND BILIARY SYSTEM abnormal liver function tests
MUSCULO-SKELETAL SYSTEM arthralgia, leg cramps, leg pain, myalgia
PSYCHIATRIC agitation, anxiety, confusion, depression, insomnia, nervousness
REPRODUCTIVE SYSTEM, MALE impotence
RESPIRATORY SYSTEM dyspnea
SKIN AND APPENDAGES alopecia, dermatitis, exfoliative dermatitis, pruritus, rash
SPECIAL SENSES alterations in taste
URINARY SYSTEM nocturia, urinary frequency
Rare, serious disorders with no definitive cause and effect relationship to guanfacine have been reported spontaneously and/or in the postmarketing
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