William C Black MD conducted unethical medical experiments on children. He wrote a report about an experiment in which he had infected a 12-month old baby with herpes. Francis Payton Rous, editor of the Journal of Experimental Medicine, rejected Black’s manuscript and wrote an editorial in the Journal stating:
Dr. Payton Rous 1966 Nobel Prize Winner
“I cannot let this occasion pass without saying that in my personal view th inoculation of a twelve month old infant with herpes virus obtained from an adult was an abuse of power, an infringement of the rights of an individual, and not excusable because the illness which followed had implications for science. The statement that the child was ‘offered as a volunteer’ – whatever that may mean – does not palliate the action.(Rous, 1941, quoted by Michael Grodin and Leonard Glanz. Children as Research Subjects: Science, Ethics, and Law, 1994)
Nevertheless, Black published his report in the Journal of Pediatrics, 1942. Black selected at random, 23 children from his patients and injected them with infected herpes tissues to demonstrate symptoms that were caused by a single herpes virus. (Timothy Murphy. The Ethics of Research with Children, AMA, 2003)
Dr. Rous received the Nobel prize 50 years after he discovered the transmittable virus causing sarcoma cancer in chickens, but his discovery had been rejected by most pathologists. For about forty years his momentous discovery had little impact, because scientists were not prepared to think of viruses as agents of cancer.
Richard Strong, MD, a professor of tropical medicine at Harvard, conducted cholera experiments on 24 prisoners in the Philippines killing thirteen. Their deaths were attributed to the accidental substitution of bubonic plague serum for cholera. He rewarded the survivors with cigars. During the Nazi trials at Nuremberg, the defendants cited…
Luther Emmett Holt, a professor of children’s disease at Columbia University, was accused of conducting 1,000 tuberculin tests on sick and dying babies at NY Babies’ Hospital. (Grodin and Glantz, Children As Research Subjects)
Yellow fever epidemics struck the United States repeatedly in the 18th and 19th centuries. The disease was not indigenous; epidemics were imported by ship from the Caribbean. Dr. Reed decided against self-experimentation and injected 22 Spanish immigrant workers in Cuba instead with the agent for yellow fever. He paid them…
“The eternal providence has appointed me to watch over the life and health of Thy creatures. May the love for my art actuate me at all time; may neither avarice nor miserliness, nor thirst for glory or for a great reputation engage my mind; for the enemies of truth and…
Giuseppe Sanarelli, MD, Italian bacteriologist injects the bacillus causing yellow fever five patients without their consent. Three of the five patients died. Dr. William Osler publicly admonished Sanarelli, stating: “To deliberately inject a poison of known high degree of virulency into a human being, unless you obtain the man’s sanction,…
Hideyo Noguchi, MD, of the Rockefeller Institute for Medical Research injected a syphilis preparation into 146 children — 100 were institutionalized and 46 were healthy — in an attempt to develop a skin test for syphilis. Several parents sued Dr. Noguchi for infecting their children with syphilis. (Noguchi. Journal of…
