1714: Charles Maitland, Smallpox

U.S. Supreme Court upheld a Virginia forced sterilization statute of people considered “genetically unfit.” Harvard-educated eugenicist, Oliver Wendell Holmes’ infamous declaration, “Three generations of imbeciles are enough. . .” resulted in the forced sterilization not only of Carrie Buck of Charlottesville, Virginia, who was falsely “diagnosed” as mentally deficient and…

Biomedical research in Germany was considered the most advanced in the world — both in its development and its ethics standards. Berlin Code of Ethics (1900) guaranteed that “all medical interventions for other than diagnostic, healing, and immunization purposes, regardless of other legal or moral authorization are excluded under all…

Probably few Bible scholars or scientists are aware that Daniel—the same Daniel who was cast into the lion’s den—was also a scientist. Daniel proposed (what is now recognized as) a classic experimental design: comparing the effect of a vegetable and water diet to a diet of the king’s meat and…

U.S. Public Health Service begins a 25-year Syphilis experiment at Tuskegee, Alabama, involving 400 black sharecroppers. The purpose of the experiment was to study the natural course of untreated syphilis in Negro men. Notwithstanding the participation of black institutions, doctors and the pivotal nurse Eunice Rivers, the underlying premise of…

William C. Black, MD, selected at random, 23 children from his patients and injected them with infected herpes tissues to demonstrate symptoms that were caused by a single herpes virus. (Timothy Murphy, The Ethics of Research with Children, AMA, 2003) M Hines Roberts described in a major medical journal an…