William C Black MD conducted unethical medical experiments on children. He wrote a report about an experiment in which he had infected a 12-month old baby with herpes. Francis Payton Rous, editor of the Journal of Experimental Medicine, rejected Black’s manuscript and wrote an editorial in the Journal stating:
Dr. Payton Rous 1966 Nobel Prize Winner
“I cannot let this occasion pass without saying that in my personal view th inoculation of a twelve month old infant with herpes virus obtained from an adult was an abuse of power, an infringement of the rights of an individual, and not excusable because the illness which followed had implications for science. The statement that the child was ‘offered as a volunteer’ – whatever that may mean – does not palliate the action.(Rous, 1941, quoted by Michael Grodin and Leonard Glanz. Children as Research Subjects: Science, Ethics, and Law, 1994)
Nevertheless, Black published his report in the Journal of Pediatrics, 1942. Black selected at random, 23 children from his patients and injected them with infected herpes tissues to demonstrate symptoms that were caused by a single herpes virus. (Timothy Murphy. The Ethics of Research with Children, AMA, 2003)
Dr. Rous received the Nobel prize 50 years after he discovered the transmittable virus causing sarcoma cancer in chickens, but his discovery had been rejected by most pathologists. For about forty years his momentous discovery had little impact, because scientists were not prepared to think of viruses as agents of cancer.
Arthur Wentworth, MD, a pediatrician trained at Harvard Medical School, performed spinal taps on 29 babies and young children at Children’s Hospital, Boston, to determine if the procedure was harmful. Dr. John Roberts of Philadelphia, noting the non-therapeutic indication, labeled Wentworth’s procedures “human vivisection.” (Grodin and Glantz, Children As Research…
Richard Strong, MD, a professor of tropical medicine at Harvard, conducted cholera experiments on 24 prisoners in the Philippines killing thirteen. Their deaths were attributed to the accidental substitution of bubonic plague serum for cholera. He rewarded the survivors with cigars. During the Nazi trials at Nuremberg, the defendants cited…
Alfred Hess & Mildred Fish used orphans as guinea pigs in studies testing dietary factors in rickets and scurvy by withholding essential nutrients from institutionalized infants until they developed the disease. Orange juice was withheld until the infants developed hemorrhages associated with Scurvy. Konrad Bercovici, a social worker, strongly criticized…
Germany’s Ministry of the Interior issued “Guidelines for Human Experimentation” Unambiguous informed consent is mandatory; particular care must be taken when the subject is a child under 18; exploitation of patients who poor, or socially disadvantaged is prohibited; disclosure requirements — the purpose, justification, and the manner in which research…
Dr. Leo Stanley, chief surgeon at San Quentin Prison for forty years, performed a wide variety of unethical experiments — which were eugenics in nature — on hundreds of prisoners. He focused on rejuvenating their masculinity through two bizarre methods: sterilization, and by implanting them with “testicular substances” from executed…
In the first century B.C. Cleopatra devised an experiment to test the accuracy of the theory that it takes 40 days to fashion a male fetus fully and 80 days to fashion a female fetus. When her handmaids were sentenced to death under government order, Cleopatra had them impregnated and…
