October 11

The FDA and Drug Safety: A Proposal for Sweeping Changes


The FDA and Drug Safety: A Proposal for Sweeping Changes
Curt D. Furberg, MD, PhD; Arthur A. Levin, MPH; Peter A. Gross, MD;
Robyn S. Shapiro, JD; Brian L. Strom, MD, MPH

The current Food and Drug Administration (FDA) system of regulating drug safety has
serious limitations and is in need of changes. The major problems include the following:
the design of initial preapproval studies lets uncommon, serious adverse events go undetected;
massive underreporting of adverse events to the FDA postmarketing surveillance
system reduces the ability to quantify risk accurately; manufacturers do not fulfill the majority
of their postmarketing safety study commitments; the FDA lacks authority to pursue sponsors who
violate regulations and ignore postmarketing safety study commitments; the public increasingly perceives
the FDA as having become too close to the regulated pharmaceutical industry; the FDA’s safety
oversight structure is suboptimal; and the FDA’s expertise and resources in drug safety and public
health are limited. To address these problems, we urge Congress, which is ultimately responsible for
the FDA’s performance, to implement the following 5 recommendations: (1) give the FDA more direct
legal authority to pursue violations, (2) authorize the adoption of a conditional drug approval
policy, at least for selected drugs, (3) provide additional financial resources to support the safety operations,
(4) mandate a reorganization of the agency with emphasis on strengthening the evaluation
and proactive monitoring of drug safety, and (5) require broader representation of safety experts on
theFDA’sadvisory committees. Arch Intern Med. 2006;166:1938-1942

People just don’t want to think about the risks of this inherently risky business. Doctors don’t want to scare their patients or draw attention to their own prescribing mistakes. Serious safety questions about a major drug can threaten the survival of a large drug company. As a result, companies often wage aggressive campaigns against safety critics. Even the FDA [Food and Drug Administration] has a dilemma. Every time it moves to restrict or withdraw a dangerous drug, it has to face questions about why it allowed the drug to reach the market in the first place.
Thomas J. Moore1

Drug safety continues to be a major public health concern in the United States. Lazarou et al2 estimated that, in 1994, there were over 100 000 fatal drug reactions among 33 million hospital admissions; this estimate was supported by a later report.3 Sadly, there is no evidence that the adverse drug reaction (ADR) problem in the United States is diminishing. A recent Harris
poll showed a sharp decline in public confidence in the FDA.4 The negative ratings were 58% compared with 37% two years ago. One main reason is that there has been no meaningful change in our regulatory approach to drug safety during the past decades. When recommendations for improvements have been made, these tended to be only small changes in the status quo rather than a fundamental effort to fix the problems. Many of the problems at the FDA are well known. Yet, the FDA lacks the authority and resources to correct these vexing problems on its own. The solutions must come from Congress, which controls both the FDA’s legal authority and its funding. This report summarizes the underlying concerns about the FDA and drug safety and calls for sweeping changes.

Author Affiliations: Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (Dr Furberg); Center for Medical Consumers, New York, NY (Mr Levin); Departments of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ, and New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark (Dr Gross); Center for the Study of Bioethics, Medical College of Wisconsin, Milwaukee (Dr Shapiro); and Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia (Mr Strom).

**Current Bills Pending in the US Congress The Food and Drug Administration Safety Act of 2005 (S 930), introduced by Senators Grassley and Dodd, would, if passed, establish the authority and independence of postmarketing safety that are essential to the restructuring of the FDA. It would also authorize additional funding to the FDA for carrying out the Act.
The Fair Access to Clinical Trials Act of 2005 (S 470) would, if passed, require that clinical trials be registered and their results be reported. Civil monetary penalties would be charged for noncompliance. A requirement to register trials would make it more difficult to suppress unfavorable trial results.
The Pharmaceutical Research and Manufacturers Accountability Act of 2005 (HR 879), introduced by Representatives Stark and Berry, would, if passed, send drug industry CEOs and other executives to jail for a minimum of 20 years if they knowingly conceal serious adverse drug experiences. A fine of up to $2 million could also be imposed on an individual found to be in violation. In addition, the CEOs would be required by the bill to annually attest that all evidence of serious adverse effects for an approved drug has been disclosed. Also, failure to complete postmarketing studies within the time specified would lead to fines of up to $5 million for each month the study goes unfinished.

The news media’s attention to drug safety increased after the revelation in 1997 that fenfluramine-phentermine (fen-phen) caused valvular heart disease.5,6 However, the problem with unsafe drugs is mucholder.1,7 The key features of the stories of the present are the same as with previous drug tragedies. New drugs are introduced on the market with inadequate safety documentation, serious ADRs are reported from the marketplace, and a large number of patients are injured before the drugs are withdrawn or better managed. The only difference is the name of the culprit drug. Recent
drug safety concerns have focusedon cyclooxygenase-2(COX-2)inhibitors in pain relief, selective serotonin reuptake inhibitors for depression, and stimulants for treatment of attention deficit hyperactivity disorder.

TheUSCongress has responded by having high-profile hearings.8,9 Several important bills related to drug safety were introduced in 2005 (see Boxat thetopof thispage),but todate they have gone nowhere. Another SenatebillsponsoredbySenatorsEnzi andKennedywasannouncedin mid-2006.Amajordilemmafor the health carecommunityis that solving the nation’s drug safety problem requires
congressional involvement.Through the FDA, Congress is responsible for protecting the public from harmful effects of drugs. The urgency to take immediate action ought to be a bipartisan issue.

Every tragic safety lapse is followed by litigation, often on behalf of hundreds or thousands of injured patients. An important consequence has been public access to confidential internal documents circulated by drug company employees. It appears from these documents that the companies sometimes knew much more about their product’s safety problems than they revealed to the FDA, the medical profession, and/or the public.10,11 Medical professionals, including ourselves, have often called into question the effectiveness of the FDA’s approach to drug safety.12-17 Moore et al12 concluded that it was “time to act on drug safety.” In a call for safer medicines, Wood et al13 emphasized the need for an independent drug safety board. Ray and Stein14 went a step further and called for reforming drug regulations. They highlighted many of the FDA’s well-known limitations and concluded that the newly established Drug Safety Oversight Board is unlikely to succeed because of its lack of authority, resources, and independence from the FDA. Strom15 suggested, among other things, that new drugs with potential safety problems be subject to conditional approval.

This proposal also addresses the problem of unfulfilled industry commitments to conduct postmarketing safety studies (see problem 4 in the following section). Roth-Cline16 proposed that safety problems could be reduced if stricter statistical criteria for documenting efficacy were required. In an accompanying editorial, Avorn17 disagreed with that approach and pointed out many of the  recognized problems at the FDA. His recommended solution was a 2-step approval process similar to that embraced by some European countries, which requires a rereview 2 to 3 years after the initial approval. In general, these commentaries have focused on 1 or 2 specific weaknesses in the FDA’s drug safety efforts rather than presenting a more thorough review of the limitations of the drug safety assessment and assurance status quo. As a result, the recommended solutions tend to be limited in scope and rarely recognize that the US Congress holds the key to a markedly improved
and comprehensive national drug safety program.

We see 8 major problems with the current system of assessment and assurance of drug safety at the FDA.

1. The initial review for approval  often fails to detect serious ADRs.Astudy by the US  General Accounting Office (GAO) concluded that 51% of all approved drugs had at least 1 serious ADR that was not recognized during the approval process. 18 Some of this results from the conduct of short-term trials in small numbers of low-risk patients. The FDA’s reluctance or inability to require long-term trials focusing on those most likely to use a drug contributes to the problem. Another critical weakness appears to be the lack of effective review of preapproval trial protocols as it relates to drug safety.

2. The FDA’s primary resource for identifying drug safety issues after marketing is the Adverse Event Reporting System.19,20 It receives about 400 000 reports annually, primarily from drug manufacturers who are required to report serious, unexpected safety events within 15 days. A minor proportion of Adverse Event Reporting System data comes directly from health care providers and patients.20 The surveillance system is plagued by massive underreporting and insensitivity to distinguishing between druginduced and naturally occurring serious events. It has been estimated that only about 1% of all ADRs and about 10% of all serious ADRs are reported.20,21 3. Setting a threshold for action in response to ADR reports is subjective. Although many drug withdrawals have occurred simultaneously around the world, the FDA has been slow compared with the action by European regulatory agencies in some recent cases (eg, problems involving troglitazone, trovafloxacin, and tolcapone). When underreporting is combined with a high threshold for action, it has the troubling consequence of unnecessarily exposing a large number of patients to drug-related harm over a long period before regulatory action (eg, restriction or withdrawal) is taken. For example, an estimated 4 million patients were exposed to each of the 5 drugs (bromfenac, dexfenfluramine, fenfluramine, mibefradil, and terfenadine) withdrawn from the market between September 1997 and September 1998.22 4.

Performance of postmarketing safety studies is virtually out of the FDA’s control, with the majority of study commitments never initiated by the pharmaceutical industry and not pursued by the FDA. The Food and Drug Administration Modernization Act of 199723 required the
FDA to annually report the status of postmarketing commitments made by product sponsors. According to the most recent report, there were 1231 as yet unsatisfied commitments through September, 2005.24

Almost two thirds of them (n=797) were “pending” (ie, not initiated), and only 21% were ongoing or delayed. Many pending study commitments lacked any deadline for completion. The FDA has neither authority to take direct legal action against the violators nor a policy to grant conditional approval for drugs with an incomplete safety record. 5. In addition, the FDA lacks direct legal authority to hold accountable drug companies that violate its recommendations or suppress or delay submission of unfavorable trial information. Rarely does theFDAinvolve the Department of Justice in taking action against adrugcompany.

6. The FDA’s intrinsic structure is viewed by some as presenting a potential conflict of interest because the Center for Drug Evaluation and Research, the FDA center that reviews and approves drugs, also has responsibility for taking regulatory action against the drugs it previously approved when safety problems emerge in the postmarketing period. According to a recent GAO report,25 the FDA’s Office of Drug Safety, currently located within the Center for Drug Evaluation, has an unclear role in safety actions with no independent regulatory authority. Also, this report found that communication between the Office of Drug Safety and the Office of New Drugs is insufficient, and the Office of Drug  Safety staff are sometimes excluded from important meetings.

7. Another problem may relate to the source of FDA funding. Critics of theFDAhave claimed that the agency  has gotten too close to the industry it is supposed to regulate, in part because of its dependence on user fees. Indeed, each of the past 3 iterations of the Prescription Drug User Fee Act26 has required that the FDA produce or perform something of value to the pharmaceutical industry in exchange for which the industry would agree to pay the fees. Until the last iteration, theFDAwas prohibited from using any funds from user fees to support postmarketing studies of safety.

8. The shortage of FDA expertise in drug safety and public health and in its advisory committees is a limiting factor. In the cases of troglitazone, cisapride, and most recently the selective COX-2 inhibitors, recommendations by some members of the FDA’s drug safety staff were not followed, illustrating the weakness of the voices for safety.  The adherence to the congressional requirement that theFDAmust “promote diversity of viewpoints among appointed members”27 is inadequate. Only the Drug Safety and Risk Management Advisory Committee has appropriate expertise in public health, drug safety, and ethics. Symptomatic to the limited role of drug safety at the FDA, this committee is often not consulted in discussions or evaluations of potential safety problems. As the institution ultimately responsible for the public’s health, the burden is primarily on Congress to take action to improve drug safety.

Experience has shown that the FDA needsmoredirect legal authoritythan it has been granted. TheFDAshould play a more active role in decisions about the design of preapproval trials and studies. For example, medicines forchronicconditionsshouldbeevaluated in large, long-term trials. Also, to achieve the medical dictum “first do no harm,” a higher priority must be given to regulating drug safety. The FDA should exercise clearer authority to require that adequatelypowered safety trialsbecompletedprior todrug approval. The regulations need to be veryspecificonthispoint.Safetyevaluation should be given the same priority as efficacy evaluation.The new authority should also include the unilateral right of the FDA to suspend marketing or to mandate immediate withdrawal of harmful drugs. Also, expanded authority should be given to the FDA regarding drug labeling changes in the face of postmarketing safety concerns. The FDA should be able to require changes to a drug label, including the addition of black box warnings, restriction of use in selected patients, and modification of approved indications. In the absence of such authority, the FDA must engage in often protracted labeling negotiations with drug manufacturers.

For postmarketing studies, the FDA needs additional and clearer authority to hold manufacturers to their commitments and to adherence to a fundamental of sound science that all study results, whether favorable or unfavorable, must be reported to the FDA in a timely manner, accompanied by disclosure to the public and/or other follow-up action. Failure to meet postmarketing commitments should have clear consequences for the offenders, which could include fines, probation, public embarrassment, or even drug withdrawal. Senate Bill 930 (see Box on page 1939) strongly supports these recommendations.

The FDA is generally effective at reviewing and approving drugs, especially for efficacy. To strengthen the drug safety program, a high priority should be the establishment of a Center for Drug Safety. We support Senate Bill 930 that proposes the establishmentof2independent, collaborating centers within theFDA,one responsible for premarketing review and evaluation and the other for continuous postmarketing surveillance and regulation. In each case, the responsible center shouldcollaborate closely with the other to avoid loss of expertise. However, we believe that this  separation will help restore public confidence by bringing safety to equal standing with efficacy.

In a number of respects, changes in FDA operations are needed to enhance its drug safety efforts. Some may require new regulations, while others require regular and much closer performance monitoring of the FDA by Congress.

v  First, the FDA should have a “conditional approval” policy for new drugs that, at the initial hearing for approval, have clear benefits but unanswered questions regarding serious adverse events. A time-limited, conditional approval status would place pressure on the sponsors to conduct and report recommended safety studies. The European Medicine
Evaluation Agency is expected to introduce new regulations in spring 2006 making 1-year conditional approval a regulatory option. An alternative would be to follow the model used in France, Japan, and Norway and have scheduled, routine rereviews of all approved drugs 2 to 4 years after the initial approval. Another alternative would be for drugs to remain conditionally approved until certain data are available, providing an incentive to collect those postmarketing data.15

v Second, through the proposed Center for Drug Safety, the surveillance approach now consisting primarily of the Adverse Event Reporting System database should be shifted from passive / reactive to active / proactive. The FDA should be given the resources (ie, funding and staff ) by Congress to take better advantage of large, available, private and public administrative databases. These could include the Department of Veterans Affairs, Department of Defense, and large electronically sophisticated health plans such as Kaiser-Permanente and Group Health Cooperative. In a few years, the new Medicare drug benefit program (Part D) could provide critically important safety information by linking pharmacy databases with clinical patient information. Benefit would be derived
if the FDA would routinely review past drug withdrawals for lessons to be learned.

v Third, an updated approach to surveillance would also benefit from the establishment of a permanent network of collaborating drug safety centers across the United States. This program could build on the existing Centers for Education and Research in Therapeutics sponsored by the Agency for Healthcare Research and Quality (http://www.certs.hhs.gov/). Funding should preferably come from Congress through the appropriations process, rather than from the pharmaceutical industry in the form of user fees. The recent announcement from the FDA28 that 4 awards were made, giving the agency access to external databases, is a good start but is far too limited in scope and funding. Another approach to securing funding could involve imposing a prescription fee of a few cents per
prescription to be collected from the pharmaceutical companies.11,29 Given the estimate of 4 billion prescriptions in 2006, this would generate substantial funding for safety monitoring.

v Fourth, the recommended active surveillance program could benefit further by learning from the experience in other countries. Adverse event surveillance, relying on large population-based, disease-specific registries, could focus on conditions such as acute liver or renal failure, sudden cardiac death, or birth defects. The clear overrepresentation of use of suspected drugs in these disease-specific databases would be potential signals of harmful drug effects. Similarly, registries could be drug based and setting based. This approach would complement the MedWatch program.

v Fifth, the current MedWatch program, which has been characterized as “fundamentally a 1950-era approach,” 30 ought to be streamlined by refocusing on its strength—the detection of rare, serious conditions.

v Sixth, the composition of all FDA advisory committees should be changed. At present, the committees are made up mostly of subspecialty experts who often receive significant support from pharmaceutical companies for clinical investigations and expert opinions. This introduces a potential for conflicts of interest and bias. For example, whether such biases were present at the FDA hearings on selective COX-2 inhibitors and muraglitazar cannot be definitively determined.31-33 Nevertheless, when the votes at the COX-2 inhibitor hearings were analyzed, a significant relationship was apparent between voting patterns and industry ties,34 although this observation could also have been due to different perspectives based on professional backgrounds.

Although subspecialty experts and investigators are critical to understanding the benefits and utility of a new drug under consideration, they should comprise no more than half of the committee members. The other half of each advisory committee should be made up of experts with diverse perspectives including risk management, drug safety, public health, epidemiology, health services research, and ethics. This should help ensure more objective and balanced recommendations from advisory committees and improve public confidence in the new drug approval and postmarketing safety surveillance processes.

The drug industry and research community can point with pride to the development and diffusion of innovative drugs that have helped ameliorate deadly and debilitating medical conditions. However, the public health benefit of these products will be negated if they cause substantial harm to users and if the public lacks trust in their safety. Therefore, assuring the safety of medical products and restoring the public’s trust that the medical products they rely on are safe for their intended use are critically important public health objectives. We have outlined a large number of current problems at the FDA and an aggressive action plan to solve them. It is now up to Congress to take the steps necessary to reinvigorate the FDA’s ability to assure the public that approved medical products are safe. For Congress not to act now would be, in our opinion, an unfortunate missed opportunity for positive change.

We urge Congress, which is ultimately responsible for the FDA’s performance, to implement the following 5 recommendations:
(1) give the FDA more direct legal authority to pursue violations,
(2) authorize the adoption of a conditional drug approval policy, at least for selected drugs,
(3) provide additional financial resources to support the safety operations,
(4) mandate a reorganization of the agency with emphasis on strengthening the evaluation and proactive monitoring of drug safety, and
(5) require broader  representation of safety experts on the FDA’s advisory committees.

Accepted for Publication: July 25, 2006.
Correspondence: Curt D. Furberg,MD,PhD,DepartmentofPublicHealth Sciences, Wake Forest University School of Medicine, Medical Center Boulevard,Winston-Salem,NC27157-1063 (cfurberg@wfubmc.edu).
Financial Disclosure:Nonereported.

Author Contributions: Study concept and design: Furberg, Levin, Gross, and Shapiro. Acquisition of data: Shapiro.
Analysis and interpretation of data: Gross and Shapiro. Drafting of the manuscript: Furberg, Levin, Gross, and Shapiro.
Critical revision of the manuscript for important intellectual content: Levin, Gross, Shapiro, and Strom. Administrative, technical, and material support: Furberg and Levin.
Study supervision: Gross.

Disclaimer: The authors are current or former members of the FDA Drug Safety and Risk Management Advisory Committee. The opinions expressed herein are their personal views.

1. Moore TJ. Prescription for Disaster: The Hidden Dangers in Your Medicine Cabinet. New York, NY: Simon & Schuster; 1998:17.
2. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998; 279:1200-1205.
3. Kelly WN. Can the frequency and risks of fatal adversedrugeventsbedetermined? Pharmacotherapy. 2001;21:521-527.
4. Goozner M. Public’s faith in FDA shows sharp slide. May 24, 2006. http://gooznews.com. Accessed August 8, 2006.
5. Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluraminephentermine. N Engl J Med. 1997;337:581-588.
6. Mundy A. Dispensing With the Truth: The Victims, the Drug Companies, and the Dramatic Story Behind the Battle Over Fen-phen. New York, NY: St Martin’s Press; 2001.
7. MooreTJ.Deadly Medicine:WhyTens of Thousands  of Heart Patients Died in America’s Worst Drug Disaster. New York, NY: Simon & Schuster; 1995.
8. US Senate, Committee on Finance. Opening statement of US Senator Chuck Grassley of Iowa, Chairman, Senate Committee on Finance: hearing—FDA, Merck and Vioxx: putting patient safety first? November 18, 2004. http://finance.senate.gov/hearings/statements/111804cg.pdf. Accessed August 8, 2006.
9. Committee on Government Reform. Opening statement of Chairman Tom Davis: risk and responsibility: the roles of FDA and pharmaceutical companies in ensuring the safety of approved drugs,
like Vioxx. May 5, 2005. http://reform.house.gov /GovReform/Hearings/EventSingle.aspx?EventID=26298. Accessed August 8, 2006.
10. Psaty BM, Furberg CD, Ray WA, et al. Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis. JAMA. 2004; 292:2622-2631.
11. Caplovitz A; The New Jersey Public Interest Research Group Law and Policy Center. Turning Medicine Into Snake Oil: How Pharmaceutical Marketers Put Patients at Risk . May 2006. http://njpirg
.org/reports/TurningMedintoSnakeOil.pdf. Accessed August 8, 2006.
12. Moore TJ, Psaty BM, Furberg CD. Time to act on drug safety. JAMA. 1998;279:1571-1573.
13. Wood AJJ, Stein CM, Woosley R. Making medicines safer—the need for an independent drug safety board. N Engl J Med. 1998;339:1851-1854.
14. Ray WA, Stein CM. Reform of drug regulation—beyond an independent drug safety board. N Engl J Med. 2006;354:194-201.
15. Strom BL. How the US drug safety system should be changed. JAMA. 2006;295:2072-2075.
16. Roth-Cline MD. Clinical trials in the wake of Vioxx:requiring statistically extreme evidence of benefit to ensure the safety of new drugs. Circulation. 2006;113:2253-2259.
17. Avorn J. Evaluating drug effects in the post-Vioxx world: there must be a better way. Circulation. 2006;113:2173-2176.
18. US General Accounting Office. FDA Drug Review: Post-approval Risks, 1976-85. Washington, DC: US General Accounting Office; April 26, 1990. GAO/PEMD 90-15.
19. Wysowski DK, Swartz L. Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions. Arch Intern Med. 2005;165:1363-1369.
20. Kessler DA. Introducing MEDWatch: a new approach to reporting medication and device adverse events and product problems. JAMA. 1993; 269:2765-2768.
21. Scott HD, Rosenbaum SE, Waters WJ, et al. Rhode Island physicians’ recognition and reporting of adverse drug reactions. R I Med J. 1987; 70:311-316.
22. Friedman MA, Woodcock J, Lumpkin MM, Shuren JE, Hass AE, Thompson LJ. The safety of newly approved medicines: do recent market removals mean there is a problem? JAMA. 1999;281:
23. Food and Drug Administration Modernization Act of 1997. Pub L No. 105-115, 111 Stat 2296 (1997). 24. Food and Drug Administration. Report on the performance of drug and biologics firms in conductingpost-marketingcommitmentstudies:availability. 71 Federal Register 10978-10979 (2006).
25. United States Government Accountability Office. Drug Safety: Improvement Needed in FDA’s Postmarket Decision-Making and Oversight Process. Washington, DC: US Government Accountability Office; March 2006. GAO-06-402 FDA Postmarket Drug Safety.
26. Prescription Drug User Fee Act of 1992. Pub L No. 102-571, 106 Stat 4491 (1992).
27. Croley SP. Practical guidance on the applicability of the Federal Advisory Committee Act.AmUniversity Administrative Law J. 1996;1996:111-178.
28. FDA Awards Contracts on Databases of Adverse Effects of Marketed Drugs: Ability to Monitor Approved Drugs Enhanced. Food and Drug Administration. October 7, 2005. Talk paper T05-30. http://www.fda.gov/bbs/topics/answers/2005/ans01368.html. Accessed January 6, 2006.
29. Joint Commission on Prescription Drug Use. Report of the Joint Commission on Prescription Drug Use: Final Report. Rockville, Md: Joint Commission on Prescription Drug Use Inc; 1990.
30. Strom BL. Potential for conflict of interest in the evaluation of suspected adverse drug reactions: a counterpoint. JAMA. 2004;292:2643-2646.
31. Mukherjee D, Nissen SE, Topol EJ. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA. 2001;286:954-959.
32. TMT review of COX-2 committee voting. March 2, 2005. http://www.masterdocs.com/voting .htm. Accessed January 16, 2005.
33. Nissen SE, Wolski K, Topol EJ. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA. 2005;294:2581-2586.
34. Center for Science in the Public Interest. Conflicts of interest on COX-2 panel: research from CSPIs Integrity in Science Project. February 25, 2005. http://www.cspinet.org/integrity/press/200502251.html. Accessed January 22, 2006.

Editor’s Note
The article by Furberg et al was submitted by the authors through the standard unsolicited manuscripts mechanism. It underwent outside peer review and was accepted as a Special Article. We
welcome comments from readers regarding other possible assessments and approaches.

Philip Greenland, MD

©2006 American Medical Association. All rights reserved.
Downloaded from www.archinternmed.com at N/A, on October 10, 2006

Subscribe To Our Newsletter!

Sign up and be the first to find out the latest news and articles about what's going on in the medical field.

You may also like

November 21, 2023

Vera Sharav is joining Christine Anderson as special guest for the Make It Your Business event in

Read More
Vera Sharav Joins Christine Anderson for Make It Your Business – Dec 4, 2023 in New Jersey

November 21, 2023

Vera Sharav is premiering the movie Never Again is Now Global in New York City, December 1.

Read More
Never Again is Now Global – Premiere Screening – Dec 1, 2023 in New York City